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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Let-7 microRNA precursor ： ウィキペディア英語版 Let-7 microRNA precursor The Let-7 microRNA precursor was identified from a study of developmental timing in ''C. elegans'', and was later shown to be part of a much larger class of non-coding RNAs termed microRNAs. miR-98 microRNA precursor from human is a let-7 family member. Let-7 miRNAs have now been predicted or experimentally confirmed in a wide range of species ((MIPF0000002 )). miRNAs are initially transcribed in long transcripts (up to several hundred nucleotides) called primary miRNAs (pri-miRNAs), which are processed in the nucleus by Drosha and Pasha to hairpin structures of about ~70 nucleotide. These precursors (pre-miRNAs) are exported to the cytoplasm by exportin5, where they are subsequently processed by the enzyme Dicer to a ~22 nucleotide mature miRNA. The involvement of Dicer in miRNA processing demonstrates a relationship with the phenomenon of RNA interference. == Genomic Locations == In human genome, the cluster ''let-7a-1/let-7f-1/let-7d'' is inside the region B at 9q22.3, with the defining marker ''D9S280-D9S1809''. One minimal LOH (loss of heterozygosity) region, between loci ''D11S1345-D11S1316'', contains the cluster ''miR-125b1/let-7a-2/miR-100''. The cluster ''miR-99a/let-7c/miR-125b-2'' is in a 21p11.1 region of HD (homozygous deletions). The cluster ''let-7g/miR-135-1'' is in region 3 at 3p21.1-p21.2. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Let-7 microRNA precursor」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.